We have fabricated silicon nanoscale pores and examined their electrokinetic transport behaviors. We have shown that nanoscale pores in series with microchannels can exhibit asymmetric concentration polarization that can be leveraged for DNA sequencing, biomolecule separation, and desalination, for example. We have also functionalized the pore with antibodies in the goal of developing nanofluidic biosensors. In the presence of the target antigen the electrical conductance of the pore is modified.
