Nano-bio Interface

This work is to understand the mechanisms and conditions under which engineered nanomaterials can cause disruption of, and passive transport through, simplified model of artificial cell membranes, namely lipid bilayers. We believe that under some conditions engineered, ENMs, can passively translocate across, and cause nanoscale defects in lipid membranes, which plays a role in cellular toxicity.

Representative Publications
1. W-C. HOU, B.Y. MOGHADAM, P.K. WESTERHOFF, & J.D. POSNER. 2011. Distribution of Fullerene Nanomaterials between Water and Model Biological Membranes. Langmuir, 27(19), 11899–11905.

2. W-C. HOU, B.Y. MOGHADAM, C. CORREDOR, P. WESTERHOFF, & J.D. POSNER. 2012 Distribution of Functionalized Gold Nanoparticles between Water and Lipid Bilayers as Model Cell Membranes. Environmental Science and Technology, 46(3), 1869–1876

3. B.Y. MOGHADAM, W-C HOU, C. CORREDOR, P. WESTERHOFF, & J.D. POSNER. 2012. Role of Nanoparticle Surface Functionality in the Disruption of Model Cell Membranes, Langmuir, 28 (2), 16318−16326

4. W-C. HOU, P. WESTERHOFF, and J.D. POSNER. 2013. Biological accumulation of engineered nanomaterials: a review of current knowledge, Environ. Sci.: Processes Impacts, 2013, 15, 103

5. C. CORREDOR, W-C HOU, S.A. KLEIN, B.Y. MOGHADAM, M. GORYLL, P. WESTERHOFF, J.D. POSNER. 2013. Disruption of Model Cell Membranes Induced by Multiwalled Carbon Nanotubes. Carbon, 2013, 60, 67-75

6. A. NEGODA, Y. LIU, W-C. HOU, C. CORREDOR, B.Y. MOGHADAM, C. MUSOLFF, L. LI, W. WALKER, P. WESTERHOFF, A.J. MASON, P. DUXBURY, J.D. POSNER, R.M. WORDEN. 2013. Engineered Nanomaterial Interactions with Bilayer Lipid Membranes: Screening Platforms to Assess Nanoparticle Toxicity, Int. J. of Biomedical Nanoscience and Nanotechnology, 2013, 3, 52 -83