Many lab-on-a-chip applications use samples with non-dilute suspensions of biomolecules and cells. Electrokinetic manipulation is one of favored transport mechanisms for pumping, mixing, injecting, concentrating, and separating analytes in micro and nanofluidic devices. We are interested in the behavior of non-dilute colloidal suspensions in these confined geometries. We are interested in two main phenomena 1) the modification of electroosmosis and electrophoresis in non-dilute suspensions and 2) the “jamming” phenomena at moderate to high particle volume fractions.